수율이 증대된 줄기세포 유래 세포외소포 생산 방법
특허 국내 출원 10-2024-0066726 / 2024.05
특허 PCT 출원 PCT/KR2025/006853 / 2025.05

Effect of Mechanical Environment Alterations in 3D Stem Cell Culture on the Therapeutic Potential of Extracellular Vesicles
WY Kang, S Jung, H Jeong, HM Woo, MH Kang, H Bae, JM Cha*
Biomaterials Research 29:Article 0189

Freeze-dry protective agent for extracellular vesicle
JM Cha, WY Jang, EH kim, EK Shin, JB Ban
US Patent App. 18/288,646 / July 4th 2024

세포외소포체 동결건조 보호제
특허 국내 출원 10-2022-0052810 / 2022.04
특허 국내 등록 제 10-2720159 / 2024.10
특허 PCT 출원 PCT/KR2022/006105 / 2022.04

수율이 증대된 줄기세포 유래 세포외소포 생산 방법
특허 국내 출원 10-2024-0066726 / 2024.05

Lyoprotectant Constituents Suited for Lyophilization and Reconstitution of Stem Cell-derived Extracellular Vesicles
WY Kang, EK Shin, EH Kim, M Kang, CY Bang, OY Bang, JM Cha*
Biomaterials Research 28:Article 0005

Mesenchymal Stem Cell-Extracellular Vesicle Therapy for Stroke: Scalable Production and Imaging Biomarker Studies
JP Son, EH Kim, EK Shin, DH Kim, JH Sung, MJ Oh, JM Cha, M Chopp, OY Bang
STEM CELLS Translational Medicine 12 (7), 459-473

Method for producing stem cell-derived extracellular vesicle
JM Cha, OY Bang, GJ Moon, EK Shin
US Patent App. 16/097,452 / May 16th 2019
US Patent Registered 11/643,638 / May 9th 2023

State of the Art Techniques for Promoting Tissue Regeneration: Combination of Three-Dimensional Bioprinting and Carbon Nanomaterials
IS Raja, MS Kang, SW Hong, H Bae, B Kim, YS Hwang, JM Cha*, DW Han*
International Journal of Bioprinting 9 (1), 181- 198

Preclinical Study of Human Bone Marrow-derived Mesenchymal Stem Cells Using a Three-dimensional Manufacturing Setting for Enhancing Spinal Fusion
SM Cho, H Choi, H Jeong, SY Kwon, EJ Roh, K Jeong, I Baek, BJ Kim, S Lee, I Han, JM Cha*
STEM CELLS Translational Medicine 11 (10), 1072-1088

Stem cell-derived microvesicles with enhanced efficacy, use thereof, and method for enhancing efficacy
OY Bang, EH Kim, JM Cha
US Patent App. 16/600,919 / Apr 30th 2020
US Patent Registered 11/351,119 / Jun 7th 2022

Development of a Novel Perfusion Rotating Wall Vessel Bioreactor with Ultrasound Stimulation for Mass-production of Mineralized Tissue Constructs
JM Cha*, YS Hwang, DK Kang, J Lee, ES Cooper, A Mantalaris
Tissue Engineering and Regenerative Medicine 19, 739-754

Improving Printability of Digital-Light-Processing 3D Bioprinting via Photoabsorber Pigment Adjustment
JW Seo, GM Kim, Y Choi, JM Cha, H Bae
International Journal of Molecular Sciences 13, 5428

(Book Chapter) Mesenchymal Stem Cell-Extracellular Vesicle Therapy in Patients with Stroke
OY Bang, EH Kim, GJ Moon, JM Cha
Handbook of Stem Cell Therapy, Springer, Singapore (ISBN: 978-981-16-6016-0)

효능이 증진된 줄기세포 유래 미세소포, 이의 용도 및 효능 강화 방법
특허 국내 출원 10-2019-0127212 / 2019.10
특허 국내 등록 제 10-2320800 / 2021.10

미분화 줄기세포 스페로이드를 포함하는 이식용 조성물
특허 국내 출원 10-2021-0086606 / 2021.07

Optimization of Polysaccharide Hydrocolloid for the Development of Bioink with High Printability/Biocompatibility for Coextrusion 3D Bioprinting
W Lim, SY Shin, JM Cha, H Bae
Polymers 13 (11), 1773

3D-Bioprinting Strategies Based on In Situ Bone Healing Mechanism for Vascularized Bone Tissue Engineering
YL Park, K Park*, JM Cha*
Micromachines 12 (3), 287

하이드로겔의 기계적 강도를 이용한 줄기세포 유래 세포외 소포체의 혈관신생 관련 사이토카인 조절 방법
특허 국내 출원 10-2019-0034596 / 2019.03
특허 국내 등록 제 10-2204648 / 2021.01
특허 PCT 출원 PCT/KR2019/005186 / 2019.04

Next-Generation Wearable Biosensors Developed with Flexible Bio-Chips
D Nam, JM Cha*, K Park*
Micromachines 12 (1), 64

Kappa-Carrageenan-Based Dual Crosslinkable Bioink for Extrusion Type Bioprinting
W Lim, GJ Kim, HW Kim, J Lee, X Zhang, MG Kang, JW Seo, JM Cha, ...
Polymers 12 (10), 2377

Injectable hydrogel derived from chitosan with tunable mechanical properties via hybrid-crosslinking system
JW Seo, SR Shin, M Lee, JM Cha, KH Min, SC Lee, SY Shin, H Bae
Carbohydrate Polymers 251, 117036

줄기세포 스페로이드로부터 유래된 조직 비드를 포함하는 이식용 조성물
특허 국내 출원 10-2019-0145787 / 2019.11

줄기세포 유래의 세포외 소포체 생산 방법
특허 국내 출원 10-2016-0053026 / 2016.04
특허 국내 등록 제 10-1991038호 / 2019.06

하이드로겔의 기계적 강도를 이용한 줄기세포의 유전자 발현 조절 방법
특허 국내 출원 10-2019-0034575 / 2019.03

Nanogels Derived from Fish Gelatin: Application to Drug Delivery System
MG Kang, MY Lee, JM Cha, JK Lee, SC Lee, J Kim, YS Hwang, H Bae
Marine drugs 17 (4), 246

Bioreactor systems are essentially required for stem cell bioprocessing
​JM Cha*, MY Lee, J Hong
Precision and Future Medicine 3 (1), 19-23​

Closed-type pre-treatment device for point-of-care testing of sputum
HJ Park, A Woo, JM Cha, KS Lee, MY Lee
Scientific Reports 8 (1), 17994

Toward an Exosome-Based Therapeutic Strategy in Regenerative Dentistry
YH Lee, IK Kwon, JM Cha
Biomedical Journal of Scientific and Technical Research 12 (1), 1-4

Marine Biomaterial-Based Bioinks for Generating 3D Printed Tissue Constructs
X Zhang, GJ Kim, MG Kang, JK Lee, JW Seo, JT Do, K Hong, JM Cha, ...
Marine Drugs 16 (12), 484

Application of mesenchymal stem cell-derived extracellular vesicles for stroke: biodistribution and microRNA study
GJ Moon, JH Sung, DH Kim, EH Kim, YH Cho, JP Son, JM Cha, OY Bang
Translational stroke research, 1-13

Serum-mediated Activation of Bone Marrow–derived Mesenchymal Stem Cells in Ischemic Stroke Patients: A Novel Preconditioning Method
GJ Moon, YH Cho, DH Kim, JH Sung, JP Son, S Kim, JM Cha, OY Bang
Cell transplantation 27 (3), 485-500

Regulation of therapeutic compounds in extracellular vesicles by 3Dorganizing different physical interactions between mesenchymal stem cells and culture matrices
S Jung, T Kim, J Kim, H Bae, OY Bang, JM Cha*
Journal of Extracellular Vesicles 7, 137

Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells
JM Cha, EK Shin, JH Sung, GJ Moon, EH Kim, YH Cho, HD Park, H Bae, ...
Scientific Reports 8 (1), 1171​

Dicalcium phosphate coated with graphene synergistically increases osteogenic differentiation in vitro
JJ Lee, YC Shin, SJ Song, JM Cha, SW Hong, YJ Lim, SJ Jeong, DW Han, ...
Coatings 8 (1), 13

Mesoderm lineage 3D tissue constructs are produced at large‐scale in a 3D stem cell bioprocess
JM Cha, A Mantalaris, S Jung, Y Ji, OY Bang, H Bae
Biotechnology journal 12 (9), 1600748

A novel cylindrical microwell featuring inverted-pyramidal opening for efficient cell spheroid formation without cell loss
JM Cha, HD Park, EK Shin, JH Sung, O Kim, W Jung, OY Bang, J Kim
Biofabrication 9 (3), 035006

Non-thermal acoustic treatment as a safe alternative to thermosensitive liposome-involved hyperthermia for cancer therapy
W Um, S Kwon, DG You, JM Cha, HR Kim, JH Park
RSC Advances 7 (47), 29618-29625

Skin penetration-inducing gelatin methacryloyl nanogels for transdermal macromolecule delivery
J Kim, R Gauvin, HJ Yoon, JH Kim, SM Kwon, HJ Park, SH Baek, JM Cha, ...
Macromolecular Research 24 (12), 1115-1125

Improvement of antitumor efficacy by combination of thermosensitive liposome with high-intensity focused ultrasound
JM Cha, DG You, EJ Choi, SJ Park, W Um, J Jeon, K Kim, IC Kwon, ...
Journal of Biomedical Nanotechnology 12 (9), 1724-1733

Cold Water Fish Gelatin Methacryloyl Hydrogel for Tissue Engineering Application
HJ Yoon, SR Shin, JM Cha, SH Lee, JH Kim, JT Do, H Song, H Bae
PloS one 11 (10), e0163902

Adult Stem Cell Therapy for Stroke: Challenges and Progress
OY Bang, EH Kim, JM Cha, GJ Moon
Journal of Stroke 18 (3), 256-266

Dynamic three‐dimensional micropatterned cell co‐cultures within photocurable and chemically degradable hydrogels
S Sugiura, JM Cha, F Yanagawa, P Zorlutuna, H Bae, A Khademhosseini
Journal of tissue engineering and regenerative medicine 10 (8), 690-699

Embryoid body size-mediated differential endodermal and mesodermal differentiation using polyethylene glycol (PEG) microwell array
JM Cha, H Bae, N Sadr, S Manoucheri, F Edalat, K Kim, SB Kim, IK Kwon, ...
Macromolecular Research 23 (3), 245-255

Composition for delivery of angiogenesis inducing molecule and artificial tissue prepared by the composition
JM Cha, MS Kim, HR Kim, ES Park
US Patent App. 14/243,700

Formulation optimization and in vivo proof-of-concept study of thermosensitive liposomes balanced by phospholipid, elastin-like polypeptide, and cholesterol
SM Park, JM Cha, J Nam, MS Kim, SJ Park, ES Park, H Lee, HR Kim
PloS one 9 (7), e103116

Optimized Protocol for the Use of Thermo-sensitive Liposome in Tumor Therapeutics
JM Cha, EJ Choi, SJ Park, SO Song, SM Park, KS Choi, ES Park, HR Kim
MRS Online Proceedings Library Archive 1625

Development of functional biomaterials with micro‐and nanoscale technologies for tissue engineering and drug delivery applications
​H Bae, H Chu, F Edalat, JM Cha, S Sant, A Kashyap, AF Ahari, CH Kwon, ...
Journal of tissue engineering and regenerative medicine 8 (1), 1-14

Improving embryonic stem cell expansion through the combination of perfusion and bioprocess model design
D Yeo, A Kiparissides, JM Cha, C Aguilar-Gallardo, JM Polak, E Tsiridis, ...
PLoS One 8 (12), e81728

Directed differentiation of size‐controlled embryoid bodies towards endothelial and cardiac lineages in RGD‐modified poly (ethylene glycol) hydrogels
L Schukur, P Zorlutuna, JM Cha, H Bae, A Khademhosseini
Advanced healthcare materials 2 (1), 195-205​

Engineering approaches toward deconstructing and controlling the stem cell environment
F Edalat, H Bae, S Manoucheri, JM Cha, A Khademhosseini
Annals of biomedical engineering 40 (6), 1301-1315

Microfabricated biomaterials for engineering 3D tissues
P Zorlutuna, N Annabi, G Camci‐Unal, M Nikkhah, JM Cha, JW Nichol, ...
Advanced materials 24 (14), 1782-1804

(Book Chapter) Microtechnological Approaches in Stem Cell Science
F Edalat, JM Cha, H Bae, S Manoucheri, SB Kim, A Khademhosseini
Chapter 9 in Regenerative Bio-Medicine and Cell Therapy Book 1: Advances in Stem Cell Research, Humana Press-Springer (ISBN: 978-1-61779-939-6)

Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation
SR Shin*, H Bae*, JM Cha*, JY Mun, YC Chen, H Tekin, H Shin, S Farshchi, ...
ACS nano 6 (1), 362-372​
*these authors are equally contributed

A cell-based biosensor for real-time detection of cardiotoxicity using lensfree imaging
SB Kim, H Bae, JM Cha, SJ Moon, MR Dokmeci, DM Cropek, ...
Lab on a Chip 11 (10), 1801-1807​

Simvastatin induces osteogenic differentiation of murine embryonic stem cells
J Pagkalos, JM Cha, Y Kang, M Heliotis, E Tsiridis, A Mantalaris
Journal of bone and mineral research 25 (11), 2470-2478​

(Book Chapter) Functional Genes and Proteins for Regenerative Medicine
S Chang, JM Cha
Chapter 9 in II. Biologic and Molecular Basis, Regenerative Medicine the Third Edition​, Koonja Publisher (ISBN: 978-8-962782-60-8)

(Book Chapter) Integrated 3-Dimensional Expansion and Osteogenic Differentiation of Murine Embryonic Stem Cells
WL Randle, JM Cha, Y Hwang, KLA Chan, SG Kazarian, JM Polak, A Mantalaris
Chapter 16 in Advances in Tissue Engineering Volume 2: Stem Cells, Mary Ann Liebert (ISBN: 978-1-934854-24-2)

The incorporation of 70s bioactive glass to the osteogenic differentiation of murine embryonic stem cells in 3D bioreactors
J Zhang, M Wang, JM Cha, A Mantalaris
​Journal of tissue engineering and regenerative medicine 3 (1), 63-71

Stem cell bioprocessing: fundamentals and principles
MR Placzek, IM Chung, HM Macedo, S Ismail, T Mortera Blanco, M Lim, JM Cha,...
Journal of the Royal Society interface 6 (32), 209-232

Integrated 3-dimensional expansion and osteogenic differentiation of murine embryonic stem cells
WL Randle, JM Cha, YS Hwang, KLA Chan, SG Kazarian, JM Polak, ...
Tissue engineering 13 (12), 2957-2970

Mechanotransduction of cardiomyocytes interacting with a thin membrane transducer
J Park, IC Kim, JM Cha, S Park, J Lee, B Kim
Journal of Micromechanics and Microengineering 17 (6), 1162

Preparation and characterization of biodegradable anti-adhesive membrane for peritoneal wound healing
SN Park, HJ Jang, YS Choi, JM Cha, SY Son, SH Han, JH Kim, WJ Lee, ...
Journal of Materials Science: Materials in Medicine 18 (3), 475-482​

Construction of functional soft tissues from premodulated smooth muscle cells using a bioreactor system
JM Cha, SN Park, GO Park, JK Kim, H Suh
Artificial organs 30 (9), 704-707

Guided three-dimensional growth of functional cardiomyocytes on polyethylene glycol nanostructures
DH Kim, P Kim, I Song, JM Cha, SH Lee, B Kim, KY Suh
Langmuir 22 (12), 5419-5426

Time‐dependent modulation of alignment and differentiation of smooth muscle cells seeded on a porous substrate undergoing cyclic mechanical strain
JM Cha, SN Park, SH Noh, H Suh
Artificial organs 30 (4), 250-258

Integrated 3D expansion and osteogenic differentiation of murine embryonic stem cells in a simulated microgravity bioreactor
JM Cha, WL Randle, MR Plazcek, Y Hwang, AE Bishop, JM Polak, ...
The 2006 Annual Meeting​

Contractile force measurement of cardiomyocytes using a hybrid biopolymer microcantilever array
J Ryu, J Park, S Choi, E Seo, JM Cha, S Ryu, J Kim, SH Lee, B Kim
Digest of Papers Microprocesses and Nanotechnology 2005, 208-209

Real-time measurement of the contractile forces of self-organized cardiomyocytes on hybrid biopolymer microcantilevers
J Park, J Ryu, SK Choi, E Seo, JM Cha, S Ryu, J Kim, B Kim, SH Lee
Analytical chemistry 77 (20), 6571-6580

The dependence of contractile force for the cardiomyocytes on a different engineered surface
J Kim, J Park, JM Cha, S Ryu, SK Ryu, S Park, B Kim, J Cha, HC Kim, ...
SENSORS, 2005 IEEE, 4 pp.​